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Life-Span Extension

The Future



Many companies are trying to extend the life of short-lived species by using drug treatments. Such a strategy could possibly lead to drugs that lead to life prolongation and slower rates of aging. It was shown in 2000 that life extension can be achieved by drug treatment, at least in invertebrates. This is a natural extension of the genetic approach, using life span as a marker. Such a strategy could possibly lead to drugs that prolong life and slow rates of aging. For now, this still seems a distant pipe dream. However, the production of such drugs could be common in the future.



THOMAS E. JOHNSON

BIBLIOGRAPHY

ALLARD, M.; LEBRE, V., and ROBINE; J.-M. Jeanne Calment: From Van Gogh's Time to Ours. New York: W. H. Freeman, 1998.

AUSTAD, S. N. Why We Age. New York: John Wiley, 1997.

BOVA, B. Immortality. New York: Avon Books, 1998.

FINCH, C. E. Senescence, Longevity, and the Genome. Chicago: University of Chicago Press, 1990.

FINCH, C. E., and TANZI, R. E. "Genetics of Aging." Science 278 (1997): 407–411.

GUARENTE, L., and KENYON, C. "Genetic Pathways that Regulate Ageing in Model Organisms." Nature 408 (2000): 255–262.

JOHNSON, T. E., and WOOD, W. B. "Genetic Analysis of the Life-Span of Caenorhabditis Elegans." Proceedings of the National Academy of Sciences U.S.A. 79 (1982): 6603–6607.

MARTIN, G. M.; AUSTAD, S. N.; and JOHNSON, T.E. "Genetic Analysis of Ageing: Role of Oxidative Damage and Environmental Stresses." Nature Genetics 13 (1996): 25–34.

MELOV, S.; RAVENSCROFT, J.; MALIK, S.; WALKER, D. W.; CLAYTON, P. E.; WALLACE, D. C.; MALFROY, B.; DOCTROW, S. R.; and LITHGOW, G. J. "Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics." Science 289 (2000): 1567–1569.

OLSHANSKY, J. S.; CARNES, B. A.; and BUTLER, R. N. "If Humans Were Built to Last." Scientific American 284 (2001): 50–55.

PERLS, T. T., and SILVER, M. H. Living to 100: Lessons in Living to Your Maximum Potential at Any Age. New York: Basic Books, 1999.

RICKLEFS, R. E., and FINCH, C. E. Aging: A Natural History. New York: Scientific American Library, 1995.

ROSE, M. R. Evolutionary Biology of Aging. Oxford, U.K.: Oxford University Press, 1990.

VAUPEL, J. W.; CAREY, J. R.; CHRISTENSEN, K.; JOHNSON, T. E.; YASHIN, A. I.; HOLM, N. V.; IACHINE, I. A.; KANNISTO, V.; KHAZAELI, A. A.; LIEDO, P.; LONGO, V. D.; ZENG, Y; MANTON, K. G.; and CURTSINGER, J. W. "Biodemographic Trajectories of Longevity." Science 280 (1998): 855–860.

WEINDRUCH, R., and WALFORD, R. L. The Retardation of Aging and Disease by Dietary Restriction. Springfield, Ill.: Charles C. Thomas, 1988.

Additional topics

Medicine EncyclopediaAging Healthy - Part 3Life-Span Extension - Myths About Life Extension, Scientific Analysis Of Longevity, Centenarians, Life-extension Strategies That Work