Other Free Encyclopedias » Medicine Encyclopedia » Genetics in Medicine - Part 3 » Nondisjunction - The Mechanism Of Nondisjunction, Non-fatal Human Aneuploid Conditions, Fatal Versus Nonfatal Conditions, The Causes Of Nondisjunction And Its Frequency In Humans

Nondisjunction - The Causes Of Nondisjunction And Its Frequency In Humans

age chromosome spindle correct cell meiosis

Meiosis is a very tightly regulated process, and a whole series of control mechanisms (constituting a number of "checkpoints") exist to ensure that everything proceeds in the correct manner. If an error should occur during the process, it is usually corrected. Nondisjunction is the result of a mistake at the level of chromosome segregation, which involves the spindle fibers. In normal meiosis, there is a mechanism that monitors the correct formation of the spindle fibers, the correct attachment of the chromosomes to the spindle fibers, and the correct segregation of chromosomes. Collectively, this is referred to as the spindle checkpoint. Failure of this checkpoint to function correctly results in nondisjunction of chromosomes.

Nondisjunction is known to occur more frequently in the cells of older individuals. This is illustrated by the fact that older women are more likely to give birth to children affected by an aneuploid condition than are younger women. For instance, the risk of a twenty-year-old mother giving birth to a child with Down syndrome is about one in two thousand, compared to an approximate one in thirty risk in the case of a woman of age forty-five. The precise reason for this is not entirely certain, but a simple explanation could be that the older a cell is, the more loosely controlled are the processes occurring within that cell. This would mean that an older cell undergoing meiosis would be more likely than a younger one to ignore the constraints of the spindle checkpoint and hence give rise to aneuploid cells.

Andrea Bernasconi

Bibliography

Alberts, Bruce, et al. Molecular Biology of the Cell, 3rd ed. New York: Garland Publishing, 1994.

Lewin, Benjamin. Genes VII. New York: Oxford University Press, 2000.

Strachan, Tom, and Andrew P. Read. Human Molecular Genetics. Oxford, U.K.: BiosScientific Publishers, 1996.

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5 months ago



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5 months ago



شركة نقل عفش واثاث بالدمام ابيات الشرقيه لخدمات نقل العفش والاثاث بالدمام
http://abyath.net/ شركة نقل عفش بالدمام
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http://abyath.net/news/details/company-transfere-furniture-dammam-2017.html شركة نقل اثاث الدمام
http://abyath.net/news/details/furniture-transfere-dammam-now.html نقل عفش الدمام
http://abyath.net/news/details/dammam-all-company-transfere-furniture.html نقل عفش بالدمام
ان اردت نقل عفش منزلك بالدمام ابيات الشرقية من اهم شركات نقل العفش بالدمام والخبر والجبيل والقطيف والاحساء

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5 months ago




http://www.domyate.com/2015/08/30/furniture-transport-company-in-almadinah شركة نقل عفش بالمدينة المنورة
http://www.domyate.com/2016/06/05/transfer-furniture-medina-almonawara شركة نقل عفش بالمدينة المنورة
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http://www.domyate.com/2016/06/05/transfer-furniture-yanbu شركة نقل عفش بينبع
http://www.domyate.com/2016/07/02/transfer-furniture-dammam شركة نقل عفش بالدمام
http://www.domyate.com شركة نقل عفش بالدمام

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5 months ago


http://emc-mee.com/blog.html شركات نقل العفش
اهم شركات كشف تسربات المياه بالدمام كذلك معرض اهم شركة مكافحة حشرات بالدمام والخبر والجبيل والخبر والاحساء والقطيف كذكل شركة تنظيف خزانات بجدة وتنظيف بجدة ومكافحة الحشرات بالخبر وكشف تسربات المياه بالجبيل والقطيف والخبر والدمام
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5 months ago



شركة مكافحة حشرات بينبع وكذلك شركة كشف تسربات المياه بينبع وتنظيف خزانات وتنظيف الموكيت والسجاد والكنب والشقق والمنازل بينبع وتنظيف الخزانات بينبع وتنظيف المساجد بينبع شركة تنظيف بينبع تنظيف المسابح بينبع
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5 months ago


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http://jumperads.com/all-company-cleaning-tanks-medina.html اهم شركات تنظيف خزانات بالمدينة المنورة


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5 months ago




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http://jumperads.com/best-company-transfer-furniture-riyadh.html افضل شركة نقل عفش بالرياض


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5 months ago


الشرق الاوسط افضل شركة نقل عفش بالدمام شركة نقل عفش بالخبر شركة نقل عفش بالجبيل شركة نقل عفش بالقطيف تنظيف كنب بالدمام تنظيف كنب بالخبر
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5 months ago


شركة نقل اثاث بالدمام التفاؤل شركة نقل اثاث بالخبر كما انها افضل شركة نقل اثاث بالجبيل نقل عفش واثاث بالجبيل والخبر والقطيف والدمام
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6 months ago

Getting too many issues while installing Microsoft Antivirus? It is a common technical issue that usually happens and easily be resolve by getting in touch with the technical experts. They are the ones who are very knowledgeable in this field and give an immediate solution for the issues. To get a instant help from them, must follow the link http://microsoft-contact-number.co.uk/service.php.

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7 months ago

When Avast Antivirus doesn’t perform as per your desire then, you should get connected with the technicians to know how to counter the problems that become the reasons for worse performance and to know how they will do that, must visit the link http://avast-uk.uk/.

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9 months ago

www.Cumapoker com menghadirkan minimal deposit dan withdraw yang sangat rendah loh :
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11 months ago

Are you in any technical trouble with any of the Microsoft products For such situations contact technicians immediately and calling at toll-free number 0800-098-8371 Microsoft Support Number UK will make this task easy. Call the technicians of this helpline any time you want and get the issue corrected easily.for More Details Please Click Here:-http://microsofthelpnumber.co.uk/

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11 months ago

Are you having troubles in accessing your Windows and crave to distinguish how to activate a Windows. Subsequently basically converse to our glowing proficient technicians by a call at Windows Customer Care Number UK@0800-098-8312 anytime whenever you like you necessitate technical facilitate. We will fascinate you enormously from beginning to end our strong services.

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11 months ago

Norton Support Number UK provides reliable service support to the users all over United Kingdom and ensures that they remain protected from any such threats. However, the users must always remain aware of few things while using their systems for ensuring complete protection from any new online infections.
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about 1 year ago

Packers and Movers Gurgaon @ http://www.movingsupport.in/packers-and-movers-gurgaon.html

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about 1 year ago

Just call on McAfee Support Number @0800-098-8354 and avail help for anti-virus software updates and settings by using McAfee Anti-virus software. This easy and user friendly software, and everybody can use it.

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over 1 year ago

Packers and Movers Mumbai
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over 1 year ago

Packers and Movers Gurgaon
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over 1 year ago

http://packers-movers-gurgaon.in/

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over 1 year ago

http://4th.co.in/
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over 1 year ago

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over 1 year ago

http://4th.co.in/packers-and-movers-chennai/

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over 1 year ago

Movers and Packers in Chennai @ http://4th.co.in/packers-and-movers-chennai/
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over 1 year ago

Packers and Movers Bangalore or
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over 1 year ago

http://3th.co.in/packers-and-movers-mumbai/
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over 1 year ago

packers and movers noida charges @
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over 1 year ago


Packers and Movers in Pune go to:-
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over 1 year ago


Packers and Movers Bangalore go to:-
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over 1 year ago

For picking a right pressing and moving administration supplier you can ask your companions and relatives.

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over 1 year ago

The most reliable and efficient Packers and Movers service in Bangalore.Visit:-
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over 1 year ago

The most reliable and efficient Packers and Movers service in Pune.Visit:-
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