Other Free Encyclopedias » Medicine Encyclopedia » Genetics in Medicine - Part 3

Meiosis - Overview, Meiosis I, The Sources Of Genetic Diversity, Meiosis Ii, Chromosomal Aberrations - Comparison with Mitosis

differences cell cells occurs chromosomes

Meiosis is a type of cell division that, in humans, occurs only in male testes and female ovary tissue, and, together with fertilization, it is the process that is characteristic of sexual reproduction. Meiosis serves two important purposes: it keeps the number of chromosomes from doubling each generation, and it provides genetic diversity in offspring. In this it differs from mitosis, which is the process of cell division that occurs in all somatic cells.

In summary, the main differences between meiosis and mitosis are that meiosis occurs only in specialized cells rather than in every tissue; it produces haploid gametes rather than diploid somatic cells; and each daughter cell is genetically different from the others due to recombination and independent assortment of homologues, rather than genetically identical. The pairing of homologous chromosomes and crossing over occur only in meiosis.

Additional Topics

Meiosis - Overview

All of our somatic cells except the egg and sperm cells contain twenty-three pairs of chromosomes, for a total of forty-six individual chromosomes. This number, twenty-three, is known as the diploid number. If our egg and sperm cells were just like our somatic cells and contained twenty-three pairs of chromosomes, their fusion during fertilization would create a cell with forty-six chromosome pair…

Meiosis - Meiosis I

Meiosis must be preceded by the S phase of the cell cycle. This is when DNA replication (the copying of the genetic material) occurs. Thus, each chromosome enters meiosis consisting of two sister chromatids joined at the centromere. The first stage of meiosis is a stage called prophase I. First, the DNA of individual chromosomes coils more and more tightly, a process called DNA condensation. The s…

Meiosis - The Sources Of Genetic Diversity

It is completely random whether the maternal or paternal chromosome of each pair ends up at a particular pole. The orientation of each pair of homologous chromosomes on the metaphase plate is random, and a mixture of maternal and paternal chromosomes will be drawn toward the same cell pole by chance. This phenomenon is often called "independent assortment," and it creates new combina…

Meiosis - Meiosis Ii

Once both cell poles have a haploid set of chromosomes clustered around them, these chromosomes divide mitotically (without reshuffling or reducing the number of chromosomes during division) during the second part of meiosis. This time, the spindle fibers bind to both faces of the kinetochore, the centromeres divide, and the sister chromatids move to opposite cell poles. At the end of meiosis II, …

Meiosis - Chromosomal Aberrations

Meiosis is a very intricate process that requires, among other things, the precise alignment of homologous chromosome pairs and correct attachment of microtubules. During meiosis, errors in chromosome distribution may occur and lead to chromosomal aberrations in the offspring. One example is Down syndrome, where affected children carry three copies of chromosome 21 (trisomy 21). This may be explai…

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