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Nondisjunction

The Mechanism Of Nondisjunction, Non-fatal Human Aneuploid Conditions, Fatal Versus Nonfatal Conditions, The Causes Of Nondisjunction And Its Frequency In Humans

Nondisjunction is the failure of two members of a homologous pair of chromosomes to separate during meiosis. It gives rise to gametes with a chromosomal content that is different from the norm. The consequences of this are usually quite severe, and a number of clinical conditions are the result of this type of chromosome mutation.

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Medicine EncyclopediaGenetics in Medicine - Part 3