Other Free Encyclopedias » Medicine Encyclopedia » Aging Healthy - Part 1 » Dna Damage and Repair - Dna Damage, Base Modifications In Dna After Exposures, Detection Of Dna Damage, Consequences Of Dna Damage

Dna Damage and Repair - Perspectives

age aging aging bohr research excision

DNA repair is a complex and fascinating process, and it is very interactive with other DNA metabolic processes. It is tightly linked to the transcription process and also to DNA replication and a number of signal transduction pathways. An age-associated decline in DNA repair could explain why older individuals suffer from age-associated diseases and become highly susceptible to cancer. This understanding could also lead to therapeutic interventions in the future where DNA repair activities could be enhanced.



AMES, B. N. "Endogenous Oxidative DNA Damage, Aging and Cancer." Free Radical Research Communications 7 (1998): 121–128.

BALAJEE, A. S., and BOHR, V. A. "Genomic Heterogeneity of Nucleotide Excision Repair." Gene 250 (2000): 15–30.

BOHR, V. A., and ANSON, R. M. "DNA Damage, Mutation and Fine Structure DNA Repair in Aging." Mutation Research 338 (1995): 25–34.

CROTEAU, D. L.; STIERUM, R. H.; and BOHR, V. A. "Mitochondrial DNA Repair Pathways." Mutation Research 434 (1999): 137–148.

DIZDAROGLU, M. "Chemical Determination of Free Radical-Induced Damage to DNA." Free Radical Biology and Medicine 10 (1991): 225–242.

FRIEDBERG, E. C.; WALKER, G. C.; and SIEDE, W. DNA Repair and Mutagenesis. New York: ASM Press, 1995.

HARMAN, D. "Aging: A Theory Based on Free Radical and Radiation Chemistry." Journal of Gerontology 11 (1956): 298–300.

HART, R. W., and SETLOW, R. B. "Correlation Between Deoxyribonucleic Acid Excision Repair and Life Span in a Number of Mammalian Species." Proceedings of the National Academy of Sciences of the United States of America 71 (1994): 2169–2173.

KLUNGLAND, A., and LINDAHL, T. "Secondary Pathway for Completion of Human DNA Base Excision-Repair: Reconstitution with Purified Proteins and Requirement for DNase IV (FEN1)." EMBO Journal 16 (1997): 3341–3348.

KROKAN, H. E.; STANDAL, R.; and SLUPPHAUG, G. "DNA Glycosylases in the Base Excision Repair of DNA." Biochemical Journal 325 (1997): 1–16.

LINDAHL, T. "Instability and Decay of the Primary Structure of DNA." Nature 362 (1993): 709–715.

SOUZA-PINTO, N. C.; CROTEAU, D. L.; HUDSON, E. K.; HANSFORD, R. G.; and BOHR, V. A. "Age-Associated Increase in 8-Oxo-Deoxyguanosine Glycosylase/AP Lysase Activity in Rat Mitochondria." Nucleic Acids Research 27 (1999): 1935–1942.

STIERUM, R. H.; DIANOV, G. L.; and BOHR, V. A. "Single-Nucleotide Patch Base Excision Repair of Uracil in DNA by Mitochondrial Protein Extracts." Nucleic Acids Research 27 (1999): 3712–3719.

WEI, Q.; MATANOSKI, G. M.; FARMER, E. R.; HEDAYAT, M. A.; and GROSSMAN, L. "DNA Repair and Aging in Basil Cell Carcinoma: A Molecular Epidemiology Study." Proceedings of the National Academy of Sciences of the United States of America 90 (1993): 1614–1618.

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