Other Free Encyclopedias » Medicine Encyclopedia » Genetics in Medicine - Part 3

Mosaicism - The Sex Chromosomes, Mosaic Expression, X Chromosome Inactivation, Effect Of X Inactivation On Human Disease

age aging genetic cells mitochondrial mitochondria tissues

In 1961 Mary Lyon, an English scientist, hypothesized that one of the two X chromosomes in females becomes genetically silent early in a female embryo's development. To understand how she arrived at this idea, which has come to be known as "the Lyon Hypothesis," we need to understand what was known about the sex chromosomes.

Chromosomal Mosaicism.

Every time a cell divides, the genetic material assembled in chromosomes needs to be divided too. If the chromosomes do not separate evenly, then cells are formed with missing or extra chromosomes. Such cells are called aneuploid. If this occurs early in embryonic development, a significant proportion of cells in an individual will be abnormal.

Chromosomal mosaicism may also result from the "rescue" of a fertilization that resulted from an aneuploid sperm or egg. If a fertilized egg contains three copies of a particular chromosome, a condition called trisomy, instead of the normal two, one of the extra copies can be "lost" if the chromosomes divide unevenly, restoring the normal chromosome number to the daughter cell.

Typically, in fetuses surviving the first trimester of pregnancy, the abnormal cells are found in placental but not in fetal tissues. Cells with three copies of a chromosome may be able to survive better in placental tissues, or there may be stronger selection against the growth of such cells in fetal tissues.

Trisomy is occasionally associated with pregnancy complications, such as poor fetal growth, but it may be common in placental tissues, and mosaicism confined to the placenta has been suggested to occur in up to 5 percent of births. Trisomic cells can also be found in the fetus itself, although this occurs much more rarely. Sometimes the abnormal cells will be present in only one type of tissue, such as the skin or lungs. Such variability has made it difficult to determine how often such chromosome mosaicism occurs and how it affects the health of an individual.

Mitochondrial Mosaicism.

The mitochondria are organelles in the cytoplasm that release energy stored in molecules for cells to use. They contain their own small chromosome. The mitochondrial chromosome contains 16,569 base pairs, compared with the nuclear chromosomes, which, together, contain three billion base pairs.

Two features make mitochondria prone to mosaicism. First, their DNA is mutated more frequently than the nuclear DNA, in part because of the more dangerous cellular environment facing mitochondria and in part because mitochondria are not equipped to repair mutations as effectively as the nucleus.

Second, each mitochondrion contains numerous copies of its genome, and there are thousands of mitochondria in each cell. Thus individuals can have mutations in some of their mitochondrial genomes that are not found in their other mitochondria. This can lead to variable expression of diseases associated with mitochondrial mutations. Deletions of part of the mitochondrial genome appear to accumulate in different tissues with age and have been suggested to be a critical factor in normal human aging.

Carolyn J. Brown

Bibliography

Avner, Philip, and Edith Heard. "X-Chromosome Inactivation: Counting, Choice and Initiation." Nature Reviews: Genetics 2 (2001): 59-67.

Lyon, Mary F. "Gene Action in the X-Chromosome of the Mouse (Mus musculus L.)."Nature 190 (1961): 372-373.

Internet Resource

Online Mendelian Inheritance in Man. Johns Hopkins University, and National Center for Biotechnology Information. <http://www.ncbi.nlm.nih.gov/omim>.

Hermann Muller [next] [back] Thomas Hunt Morgan - Training And Early Interests, A Lucky Discovery, Linkage And Chromosome Mapping, Morgan's Legacy

User Comments

The following comments are not guaranteed to be that of a trained medical professional. Please consult your physician for advice.

Your email address will be altered so spam harvesting bots can't read it easily.
Hide my email completely instead?

Cancel or

Vote down Vote up

23 days ago

http://medicine.jrank.org/pages/2564/Mosaicism.html

Vote down Vote up

23 days ago

Mosaicism - The Sex Chromosomes, Mosaic Expression, X Chromosome Inactivation, Effect Of X Inactivation On Human Disease

Vote down Vote up

about 1 year ago

https://t.co/HoPcE9eQpz
https://t.co/qwBue2UyZS
https://t.co/LANdpmGe5M
https://t.co/u6PnoetMzO
https://t.co/sidZNwlEXW
https://t.co/Hk6EITNzZL
https://t.co/tyIEPz4L2R
https://t.co/N38mRhom1O
https://t.co/rg2jnzZspJ
https://t.co/v76XhDZpdr
https://t.co/69HTqcC3FR
https://t.co/nuWIyNsVGy
https://t.co/UTLoBl5k7K
https://t.co/H4fBeA4c15
https://t.co/l23m0pWOJR
https://t.co/Ywua0qil9D
https://t.co/hyHdynhJ3F
https://t.co/XQcN1TZM1h
https://t.co/7qDmEE24cY
https://t.co/fE0mNwB3W2
https://t.co/QzemIpSxMC
https://t.co/zCFwYwpOFu
https://t.co/XmfLSt7NtL
https://t.co/Qc4oBknSIP
http://ufc200.org/
https://t.co/obGBS8mj9K
https://t.co/Vi7Z5SgjJl
https://t.co/UUAWGU6EmA
https://t.co/pzjXoJTQfs
https://t.co/N27Innqcj6
https://t.co/OiPHiHoMdb
https://t.co/FDOMNIEvvK
https://t.co/ZgMGdq4VHz
https://t.co/fOjWuveFwN
https://t.co/IQqJbEMaWG
https://t.co/mZBa4MtjFB
https://t.co/Jt8tnF0dLk
https://t.co/XDlK9EOy0c
https://t.co/wVRS515mvF
https://t.co/MuUbfqM4r7
https://t.co/QthAopXeVh
https://t.co/zpMXQyTCuE
https://t.co/s8qhkz63KN
https://t.co/2RXa5sDQpy
https://t.co/U62udiJvjO
http://ufc-200.co/
https://t.co/yCNDajAViM
https://t.co/mfqZgqy2eM
https://t.co/BIz2qUTb6y
https://t.co/GHWmHAAwk4
https://t.co/qcTuRJ7rhy
https://t.co/4WjN7UEZOR
https://t.co/CCnK5Qrlm9
https://t.co/PM0rPDV01j
https://t.co/8PORdw11bW
https://t.co/8GpJdvdZyK
https://t.co/1TtgmrdR0s
https://t.co/ihcU2M0lvm
https://t.co/fIreOjaTHk
https://t.co/27iokOx5ea
http://ufc-200.com/
https://t.co/oildkK2cJI
https://t.co/hvQBKQU7D0
https://t.co/r74izaRYfx
https://t.co/7zAFmOITVN
https://t.co/ig29tqZ5fH
https://t.co/LOj6zoq0t9
https://t.co/ccSBoILbqi
https://t.co/tk9YDsYjXW
https://t.co/sHWXyuGXXN
https://t.co/wxPAmrNKyf
https://t.co/RlO8lMCdNO
https://t.co/ifHm5pqsCx
https://t.co/cKUdzMhy3V
https://t.co/8xrNRXLYyw
http://ufc200stream.net/
https://twitter.com/200ufc
https://t.co/1qyQ92RUmv
https://t.co/JzmAnDW7b2
https://t.co/ERJ3ZllHBe
https://t.co/CypH7XgcNo
https://t.co/ZkVGWYNqmU
https://t.co/6kPDz4FF6u
https://t.co/xb85324kVE
https://t.co/AdbN6RMszR
https://t.co/4SRHr144kl
https://t.co/WCWMzZM2Fe
https://t.co/Hkmr2awfzB
https://t.co/rVrXm8oCQi
https://t.co/7G2DH6Fwnb
https://t.co/puneV1yxbZ
https://t.co/oFkbtTlqBA
https://t.co/YOqPQpkYM0
https://t.co/8cmrcm6oEl
https://t.co/w4shsf4AC2
https://t.co/keqL0dEivI
https://t.co/OHDu2UbZX6
https://t.co/GuzDNJI56H
https://t.co/InveweFrFo
https://t.co/tjW17m1dkO
http://cormiervsjones.net
https://t.co/sP0hqU1FCm
https://t.co/POam0yaZJo
https://t.co/vhyM4pci7U
https://t.co/Btibz3GRPy
https://t.co/Zunfhgdc0Q
https://t.co/pzEr934TQL
https://t.co/5VnXJpbbcD
https://t.co/t657JNBgoR
https://t.co/QNXbfuV14N
https://t.co/RYBzCFdc9p
https://t.co/6ZnygIwwEW

Vote down Vote up

almost 2 years ago

http://vimaximportaslicanada.com/vagina-tabung-manual-silikon/
http://vimaximportaslicanada.com/boneka-sex-full-body/
http://vimaximportaslicanada.com/vagina-pinggul-elektrik/
http://vimaximportaslicanada.com/vagina-senter-elektrik/
http://vimaximportaslicanada.com/vagina-getar-goyang/
http://vimaximportaslicanada.com/penis-getar-goyang/
http://vimaximportaslicanada.com/penis-getar-goyang/
http://vimaximportaslicanada.com/sex-toys-penggeli-vagina/
http://vimaximportaslicanada.com/penis-ikat-pinggang/
http://vimaximportaslicanada.com/penis-mutiara-getar-goyang/
http://vimaximportaslicanada.com/capsul-penggetar-vagina/
http://vimaximportaslicanada.com/alat-bantu-sex-butterflay/
http://vimaximportaslicanada.com/proextender-alat-pembesar-penis/
http://vimaximportaslicanada.com/alat-vakum-pembesar-penis/
http://vimaximportaslicanada.com/alat-pembesar-penis-celana-vakoou/
http://vimaximportaslicanada.com/kondom-badak-mutiara/
http://vimaximportaslicanada.com/kondom-sungut-lele/
http://vimaximportaslicanada.com/kondom-sambung-silikon/
http://vimaximportaslicanada.com/kondom-duri-sungut-gajah/
http://vimaximportaslicanada.com/kondom-kristal-berduri/
http://vimaximportaslicanada.com/kondom-badak-silikon/
http://vimaximportaslicanada.com/cream-pembesar-payudara/
http://vimaximportaslicanada.com/pemutih-badan-whitening/
http://vimaximportaslicanada.com/pembesar-pantat-buttooks/
http://vimaximportaslicanada.com/vakum-pembesar-payudara/
http://vimaximportaslicanada.com/emilay-pemutih-wajah/
http://vimaximportaslicanada.com/obat-pemerah-bibir-alami/
http://vimaximportaslicanada.com/obat-perapat-vagina-chien-chin/
http://vimaximportaslicanada.com/semenax-penyubur-sperma/
http://vimaximportaslicanada.com/obat-herbal-hernia/
http://vimaximportaslicanada.com/grow-peninggi-badan/
http://vimaximportaslicanada.com/obat-penggemuk-badan-kianpi/
http://vimaximportaslicanada.com/hair-tonicum-penumbuh-rambut/
http://vimaximportaslicanada.com/crystal-x-plus-perapat-vagina/
http://vimaximportaslicanada.com/cialis-tadalafil-80mg-obat-kuat/
http://vimaximportaslicanada.com/obat-kuat-viagra-usa-100mg/
http://vimaximportaslicanada.com/obat-kuat-levitra-100mg/
http://vimaximportaslicanada.com/obat-kuat-cialis-tadalafil-50mg/
http://vimaximportaslicanada.com/obat-kuat-maxman-plus/
http://vimaximportaslicanada.com/obat-kuat-cialis-20mg/
http://vimaximportaslicanada.com/procomil-spray/
http://vimaximportaslicanada.com/cream-body-slim/
http://vimaximportaslicanada.com/body-slim-herbal/
http://vimaximportaslicanada.com/pelangsing-lida-daidahua/
http://vimaximportaslicanada.com/pelangsing-badan-fatloss-jimpness/
http://vimaximportaslicanada.com/pelangsing-badan-meizitang-slimming/
http://vimaximportaslicanada.com/pelangsing-badan-abc-acay-berry/
http://vimaximportaslicanada.com/obat-pelangsing-badan-fruit-plan/
http://vimaximportaslicanada.com/vimax-izon-3d-asli-canada/
http://vimaximportaslicanada.com/klg-pills-pembesar-penis/
http://vimaximportaslicanada.com/lintah-oil-papua/
http://vimaximportaslicanada.com/vimax-import-asli-canada/
http://vimaximportaslicanada.com/pembesar-penis-maxman-capsule/
http://vimaximportaslicanada.com/pembesar-penis-vigrx-plus/
http://vimaximportaslicanada.com/obat-pembesar-penis-cobra-oil/
http://vimaximportaslicanada.com/perangsang-permen-karet/
http://vimaximportaslicanada.com/perangsang-liquid-sex/
http://vimaximportaslicanada.com/perangsang-wanita-opium-spray/
http://vimaximportaslicanada.com/perangsang-wanita-potenzol/
http://vimaximportaslicanada.com/perangsang-wanita-blue-wizard/
http://vimaximportaslicanada.com/sex-drop-perangsang-wanita/
http://vimaximportaslicanada.com/perangsang-serbuk-china/
http://vimaximportaslicanada.com/selaput-dara-buatan/
http://vimaximportaslicanada.com/terapi-kesehatan-celana-hernia/
http://vimaximportaslicanada.com/blog/jual-proextender-alat-pembesar-penis-bali/
http://vimaximportaslicanada.com/blog/jual-proextender-alat-pembesar-penis-bandung/
http://vimaximportaslicanada.com/blog/jual-proextender-alat-pembesar-penis-surabaya-sidoarjo/
http://vimaximportaslicanada.com/blog/jual-vimax-asli-canadaobat-pembesar-penis-di-batam/
http://vimaximportaslicanada.com/blog/jual-vimax-asli-pembesar-penis-permanen/
http://vimaximportaslicanada.com/blog/jual-vimax-asli-canada-di-surabaya/
http://vimaximportaslicanada.com/viberator-penggeli-puting-payudara-elektrik/
http://vimaximportaslicanada.com/obat-kuat-v6-tian-herbal-alami/
http://vimaximportaslicanada.com/neosize-xl-usa/
http://vimaximportaslicanada.com/vmenplus-asli-germany/




Vote down Vote up

almost 2 years ago

Thanks for more information about visit this link:
http://www.adword.co.in/packers-and-movers-hyderabad/
http://www.adword.co.in/packers-and-movers-mumbai/
http://www.adword.co.in/packers-and-movers-pune/

Vote down Vote up

almost 2 years ago

Thanks for more information about visit this link:
http://www.adword.co.in/packers-and-movers-bangalore/
http://www.adword.co.in/packers-and-movers-delhi/
http://www.adword.co.in/packers-and-movers-gurgaon/
http://www.adword.co.in/

Vote down Vote up

almost 2 years ago

Thanks for mour information visit:
http://top3th.co.in/packers-and-movers-gurgaon/
http://top3th.co.in/packers-and-movers-delhi/
http://top3th.co.in/packers-and-movers-navi-mumbai/
http://top3th.co.in/packers-and-movers-thane/
http://top3th.co.in/

Vote down Vote up

almost 2 years ago

Thanks More for information Visit:
http://www.export5th.in/packers-and-movers-in-gurgaon/
http://www.export5th.in/packers-and-movers-in-delhi/
http://www.export5th.in/packers-and-movers-in-noida/
http://www.export5th.in/packers-and-movers-in-chennai/
http://www.export5th.in/packers-and-movers-in-dwarka/
http://www.export5th.in/packers-and-movers-in-ghaziabad/
http://www.export5th.in/packers-and-movers-in-faridabad/

Vote down Vote up

almost 2 years ago

Thanks for More information Top 3th moving services Visit:
http://3th.co.in/packers-and-movers-delhi/
http://3th.co.in/packers-and-movers-ghaziabad/
http://3th.co.in/packers-and-movers-faridabad/
http://3th.co.in/packers-and-movers-noida/

Vote down Vote up

almost 2 years ago

Thanks for More information Export5th in packing services Visit link:
http://www.export5th.in/packers-and-movers-in-hyderabad/
http://www.export5th.in/packers-and-movers-in-mumbai/
http://www.export5th.in/packers-and-movers-in-pune/
http://www.export5th.in/packers-and-movers-in-bangalore/

Vote down Vote up

over 2 years ago

http://kokl.net/tradio/index.php?item/511
https://support.hyperic.com/display/~dewapoker/2014/09/25/Dunia+RAJAPOKER88.com+Agen+Texas+Poker+Dan+Domino+Online+Indonesia+Terpercaya
http://softwarelivre.org/masgie/blog
https://seotoolinfo.academia.edu/dewapoker
http://ic.mcu.edu.tw/zh-hant/node/9146
http://softwarelivre.org/masgie/blog
http://www.semesta.org/index.php/login/668-dewa/profile
http://www.suplemenku.com/dewapoker/
http://carnivalscene.com/new2/index.php/jomsocial/47-dewa-poker/profile
http://www.semesta.org/index.php/login/groups/viewgroup/45-kontes-seo-bernuansa-agen-poker-online
http://eweek.nenonline.org/userstory/agen-texas-poker-dan-domino-online-indonesia
http://forums.megaxus.com/showthread.php?162704-Agen-Texas-Poker-Dan-Domino-Online-Indonesia
http://www.campuppet.com/node/172828
http://carnivalscene.com/new2/index.php/jomsocial/groups/viewdiscussion/188-daunpkr-com-agen-poker-domino-online-terbaik?groupid=8
http://meninblack.wikia.com/wiki/User_blog:AGENBOLAKAKI/Sang_Raja_Kontes_Dunia_Poker_Online
http://gemsbihar.org/profitconnect1/index.php/jomsocial/groups/viewgroup/49-pokerstar88com-agen-texas-poker-dan-domino-online-indonesia-terpercaya
http://agensbobet.alumni.uii.ac.id/blog-pokerstar88-com-agen-texas-poker-dan-domino-online-indonesia-terpercaya/
http://www.semesta.org/index.php/login/groups/viewgroup/46-kontes-agen-bola-terpercaya-indonesia
http://eweek.nenonline.org/userstory/agen-judi-bola-resmi-taruhan-judi-online
http://forums.megaxus.com/showthread.php?162705-Agen-Judi-Bola-Online-Piala-Dunia
http://www.campuppet.com/node/172825
http://carnivalscene.com/new2/index.php/jomsocial/groups/viewdiscussion/187-agen-judi-togel-dan-casino-online?groupid=8
http://meninblack.wikia.com/wiki/User_blog:AGENBOLAKAKI/Kontes_Agen_Judi_Togel_Indonesia
http://forumjitu.com/showthread.php?6107-PokerStar88-com-Agen-Texas-Poker-Dan-Domino-Online-Indonesia-Terpercaya
http://forumjitu.com/showthread.php?6111-855Online-com-Agen-Bola-SBOBET-IBCBET-Casino-338A-Tangkas-Togel-Online-Indonesia
https://ieee-elearning.org/outreach/blog/index.php?postid=5450
http://dofollow.web.id/story.php?title=855online-com-agen-bola-sbobet-ibcbet-casino-338a-tangkas-togel-online-indonesia-terpercaya-
http://dofollow.web.id/story.php?title=pokerstar88-com-agen-texas-poker-dan-domino-online-indonesia-terpercaya-%7C-bunglon-blog
http://diseland.com/story.php?title=seo-855online-com-agen-bola-sbobet-ibcbet-casino-338a-tangkas-togel-online-indonesia-terpercaya
http://diseland.com/story.php?title=joged-pokerstar88-com-agen-texas-poker-dan-domino-online-indonesia-terpercaya
http://www.semesta.org/index.php/login/groups/viewgroup/47-daftar-agen-bola-terbaik-dan-terpopuler-di-indonesia
http://eweek.nenonline.org/userstory/agen-bola-sbobet-indonesia-terhangat
http://forums.megaxus.com/showthread.php?162702-Sang-Master-Agen-Bola-Terpercaya
http://www.campuppet.com/node/172833
http://carnivalscene.com/new2/index.php/jomsocial/groups/viewdiscussion/186-website-casino-sbobet-indonesia?groupid=8
http://meninblack.wikia.com/wiki/User_blog:AGENBOLAKAKI/Agen_Bola_Terpercaya_Walibola.com
http://meninblack.wikia.com/wiki/User_blog:AGENBOLAKAKI/Antrian_Website_Berbasis_Casino_Sbobet
http://bunglonblog.blogspot.com/p/tutorial-seo-pokerstar88com-agen-texas.html
http://bunglonblog.blogspot.com/2014/10/champs-pokercom.html
http://bunglonblog.blogspot.com/2014/10/olb365com-casino.html
http://bunglonblog.blogspot.com/2014/10/pasarpokercom-robot.html
http://bunglonblog.blogspot.com/2014/10/maubet8com-judi-bola.html
http://bunglonblog.blogspot.com/2014/10/itupokernet-agen-judi-domino-99-online.html
http://bunglonblog.blogspot.com/2014/06/855onlinecom-agen-bola.html
http://bunglonblog.blogspot.com/2014/07/pokerstar88com-indonesia.html
http://bunglonblog.blogspot.com/2014/10/pasarpokercom-robot.html
http://bunglonblog.blogspot.com/2014/10/maubet8com-judi-bola.html
http://bunglonblog.blogspot.com/2014/10/itupokernet-agen-judi-domino-99-online.html
http://bunglonblog.blogspot.com/2014/09/web-host.html
http://bunglonblog.blogspot.com/2014/09/winpoker.html
http://bunglonblog.blogspot.com/2014/07/kakakdewacom-agen-judi-bola.html
http://bunglonblog.blogspot.com/2014/09/judi-bola-online-itubolanet.html
http://bunglonblog.blogspot.com/2014/09/itucasinonet-agen.html
http://bunglonblog.blogspot.com/2014/09/judi-itudomino.html
http://bunglonblog.blogspot.com/2014/09/pokerbuayacom-domino.html
http://bunglonblog.blogspot.com/2014/09/inipokernet-judi-online.html
http://bunglonblog.blogspot.com/2014/06/poker757com-agen-judi-poker-online-indonesia.html
http://bunglonblog.blogspot.com/2014/08/jagadpokercom.html
http://bunglonblog.blogspot.com/2014/06/daunpokernet-agen-poker.html
http://bunglonblog.blogspot.com/2014/06/bolawin88com.html
http://seosiana.blogspot.com/
http://seosiana.blogspot.com/2014/10/enjin-olb365com.html
http://seosiana.blogspot.com/2014/10/seo-champs-pokercom.html
http://seosiana.blogspot.com/2014/10/pasarpokercom-judi.html
http://seosiana.blogspot.com/2014/10/judi-domino-99-online-itudomino.html
http://seosiana.blogspot.com/2014/10/855onlinecom-ibcbet.html
http://seosiana.blogspot.com/2014/09/pokerstar88com-poker.html
http://seosiana.blogspot.com/2014/09/seo-judi-bola-online-itubolanet.html
http://seosiana.blogspot.com/2014/09/sanggarhostcom-web-hosting-gratis-murah.html
http://vilaseo.blogspot.com/
http://bolakaca.com/sbobet-pokerstar88-com/
http://vilaseo.blogspot.com/2014/10/pasarpokercom-robot.html
http://vilaseo.blogspot.com/2014/07/pokerstar88com-online.html
http://vilaseo.blogspot.com/2014/10/itupoker-net.html
http://vilaseo.blogspot.com/2014/09/bolanet.html
http://www.semesta.org/index.php/login/groups/viewgroup/48-daftar-situs-agen-poker-online-terpercaya-di-indonesia
http://eweek.nenonline.org/userstory/situs-poker-indonesia-terpercaya-indonesia
http://forums.megaxus.com/showthread.php?162703-Situs-Pembuatan-Akun-Poker-Online
http://www.campuppet.com/node/172837
http://carnivalscene.com/new2/index.php/jomsocial/groups/viewdiscussion/185-situs-poker-uang-asli-indonesia?groupid=8
http://meninblack.wikia.com/wiki/User_blog:AGENBOLAKAKI/Menjelajah_Website_Poker_Indonesia
http://h2o.law.harvard.edu/text_blocks/7237
http://forum.lahatkab.go.id/topik-9255-aturan-cara-bermain-poker-di-mahapokercom.html
http://h2o.law.harvard.edu/text_blocks/7236
http://h2o.law.harvard.edu/medias/1376
http://forum.lahatkab.go.id/topik-9254-master-agen-sbobet-tanah-air.html
http://96.30.52.192/showthread.php/1083187-Agen-Bola-Sbobet-Populer-Walibola-com
http://96.30.52.192/member.php/524738-masgie
http://hopeful.ws/arf/member.php?action=viewpro&member=LKorff
http://webmastard.com/member.php?action=viewpro&member=DHovell
http://96.30.52.192/showthread.php/1083193-Sang-Agen-Sbobet-Bolakaca-com
http://forumjitu.com/showthread.php?6108-Agen-Sbobet-Ibcbet-Walibola-com
http://forumjitu.com/showthread.php?6109-Mahapoker-com-Situs-Poker-Uang-Asli
http://forumjitu.com/showthread.php?6110-Situs-Texas-Poker-Indonesia
http://forumjitu.com/showthread.php?6112-Agen-Bola-Tangkas-di-tangkaspro-com
http://www.slideshare.net/agenibcbet
http://www.slideshare.net/agenibcbet/agen-sbobet-walibolacom
http://btd-alpha-x.co.uk/index.php/social-hub/256-agen-sbobet/profile
http://btd-alpha-x.co.uk/index.php/social-hub/groups/viewgroup/203-walibola-com-sang-agen-sbobet-online
http://btd-alpha-x.co.uk/index.php/social-hub/groups/viewgroup/204-agen-poker-online-mahapoker-com
http://gemsbihar.org/profitconnect1/index.php/jomsocial/116-agen-sbobet/profile
http://gemsbihar.org/profitconnect1/index.php/jomsocial/groups/viewgroup/46-sang-dewa-poker-mahapokercom
http://gemsbihar.org/profitconnect1/index.php/jomsocial/groups/viewgroup/47-agen-texas-poker-online-indonesia
http://gemsbihar.org/profitconnect1/index.php/jomsocial/groups/viewgroup/48-profil-walibolacom-agen-sbobet-terbaik
http://gemsbihar.org/profitconnect1/index.php/jomsocial/events/viewevent/74-lomba-seo-berbasis-poker-online?groupid=49
http://gemsbihar.org/profitconnect1/index.php/jomsocial/116-agen-sbobet/photos
http://www.tnol.co.id/komunitas/profile/10880-agensbobet.html
http://www.tnol.co.id/komunitas/groups/viewgroup/1048-cara-bermain-poker.html
http://www.tnol.co.id/komunitas/groups/viewgroup/1049-agen-ibcbet-terpopuler-walibolacom.html
http://www.tnol.co.id/komunitas/groups/viewgroup/1050-texas-holdem-poker-indonesia.html
https://masjie.com/
https://masjie.com/pasarpoker-com-agen-judi-poker-dan-domino-online-tanpa-robot/
https://masjie.com/olb365-com-agen-judi-bola-online-agen-judi-casino-online-indonesia-terpercaya/
https://masjie.com/champspoker-com-agen-poker-online-dan-domino-online-indonesia-terpercaya/
http://www.ligagame.com/forum/index.php/topic,149503.0.html
http://www.ligagame.com/forum/index.php?action=profile;u=381938
http://bedco.org.ls/index.php/network/880-agen-sbobet/profile
http://bedco.org.ls/index.php/network/groups/viewgroup/6-situs-penyedia-game-poker-indonesia
http://bedco.org.ls/index.php/network/groups/viewgroup/7-inilah-agen-zyngapoker-online
http://bedco.org.ls/index.php/network/groups/viewgroup/8-kontes-seo-pokerstar-terbaru
http://bedco.org.ls/index.php/network/groups/viewgroup/9-bonus-dari-walibola-com-agen-sbobet
http://www.tigracon.com/chat/index.php?option=com_community&view=groups&task=viewgroup&groupid=97&Itemid=215
http://www.tigracon.com/chat/index.php?option=com_community&view=groups&task=viewgroup&groupid=98&Itemid=215
https://storify.com/agensbobett/mahapoker-com-agen-poker-online-indonesia
https://storify.com/agensbobett
https://storify.com/agensbobett/promo-walibola-com-agen-bola-sbobet
https://storify.com/agensbobett/promo-walibola-com-agen-ibcbet-online
https://storify.com/agensbobett/promo-walibola-com-agen-bola-sbobet
http://steepster.com/agensbobet
http://agensbobet.alumni.uii.ac.id/
http://agensbobet.alumni.uii.ac.id/memanajemen-game-online-ibcbet/
http://about.me/dewa.poker
https://ieee-elearning.org/outreach/blog/index.php?userid=41200
https://ieee-elearning.org/outreach/blog/index.php?postid=5448
https://ieee-elearning.org/outreach/blog/index.php?postid=5446
https://ieee-elearning.org/outreach/blog/index.php?postid=5449
http://elearning.undwi.ac.id/blog/index.php?postid=1330
https://masjie.com/
https://masjie.com/champspoker-com-agen-poker-online-dan-domino-online-indonesia-terpercaya/
https://masjie.com/pasarpoker-com-agen-judi-poker-dan-domino-online-tanpa-robot/
http://itulink.com/showthread.php?6010-Situs-Para-Dewa-Poker-Online-Indonesia
http://itulink.com/showthread.php?6011-Trik-Jitu-Bermain-Texas-Holdem-Poker-di-Agen-Poker-Online
http://itulink.com/showthread.php?6012-Perkenalkan-Profil-Agen-Ibcbet-Terbaru-Walibola-com
http://itulink.com/showthread.php?6013-Agen-Bola-Agen-Sbobet-Agen-Ibcbet-Bolakca-com
http://itulink.com/showthread.php?6014-Ligabebek-com-Agen-Bola-Terpercaya-Agen-Sbobet-Casino-Sbobet
http://elearning.unsrat.ac.id/old/blog/index.php?postid=13
http://elearning.unsrat.ac.id/old/blog/index.php?postid=14
http://www.heyabigail.com/my-profile/433-agen-sbobet.html
http://www.heyabigail.com/the-hangout/groups/viewgroup/37-agen-ibcbet-terbesar-indonesia-walibolacom.html
http://www.heyabigail.com/the-hangout/groups/viewgroup/38-bonus-legit-agen-poker-indonesia-mahapokercom.html
http://agensbobetku.kinja.com/agen-bola-sbobet-dan-agen-ibcbet-online-terbesar-1646608655
http://agensbobetku.kinja.com/
http://agensbobetku.kinja.com/website-texas-holdem-poker-dari-indonesia-1646614520
http://agensbobetku.kinja.com/daftar-situs-berbasis-agen-sbobet-dan-ibcbet-berbahasa-1646621005
http://agensbobetku.kinja.com/headline-pokerstar88-com-agen-texas-poker-dan-domino-on-1646630590
http://www.dofollow.web.id/story.php?title=agen-bola-%7C-agen-ibcbet-%7C-agen-sbobet
http://www.dofollow.web.id/story.php?title=agen-bola-agen-sbobet-agen-ibcbet
http://www.dofollow.web.id/story.php?title=dewa-poker-agen-poker-poker-online
http://www.dofollow.web.id/story.php?title=agen-poker-poker-online-dewa-poker
http://www.dofollow.web.id/story.php?title=situs-agen-bola-terpercaya-bola-tangkas-casino-sbobet
http://dofollow.web.id/story.php?title=cara-bermain-poker-di-maha-poker
http://diseland.com/story.php?title=agen-bola-agen-ibcbet-agen-sbobet
http://diseland.com/story.php?title=sang-agen-bola-agen-sbobet-agen-ibcbet
http://diseland.com/story.php?title=blog-dewa-poker-agen-poker-poker-online
http://diseland.com/story.php?title=texas-holdem-poker-dan-zyngapoker-online
http://diseland.com/story.php?title=agen-bola-terpercaya-bola-tangkas-casino-sbobet
http://diseland.com/story.php?title=cara-bermain-poker-maha-poker
http://poshpro.com/story.php?title=agen-ibcbet-terbesar-walibola-com
http://poshpro.com/story.php?title=bonus-dari-agen-sbobet-bolakaca-com
http://poshpro.com/story.php?title=agen-poker-uang-asli-mahapoker-com
http://poshpro.com/story.php?title=tips-cara-bermain-poker-online
http://poshpro.com/story.php?title=games-poker-dari-agen-holdem-poker-online
http://poshpro.com/story.php?title=agen-bola-terpercaya-ligabebek-com
http://poshpro.com/story.php?title=link-855online-com-agen-bola-sbobet-ibcbet-casino-338a-tangkas-togel-online-indonesia-terpercaya
http://poshpro.com/story.php?title=news-pokerstar88-com-agen-texas-poker-dan-domino-online-indonesia-terpercaya
http://cardho.com/story.php?title=dunia-agen-sbobet-online-bersama-walibola-com
http://cardho.com/story.php?title=agen-bola-%7C-agen-sbobet-%7C-agen-ibcbet
http://cardho.com/story.php?title=sang-agen-dewa-poker-online-indonesia
http://cardho.com/story.php?title=tutorial-cara-bermain-poker
http://cardho.com/story.php?title=agen-zyngapoker-indonesia-terpercaya
http://cardho.com/story.php?title=situs-agen-bola-tangkas-terpercaya
http://cardho.com/story.php?title=855online-com-agen-bola-sbobet-ibcbet-casino-338a-tangkas-togel-online-indonesia-terpercaya
http://cardho.com/story.php?title=pokerstar88-com-agen-texas-poker-dan-domino-online-indonesia-terpercaya-%7C-bunglon-blog
http://savinges.com/story.php?title=agen-bola-%7C-agen-ibcbet-%7C-agen-sbobet
http://savinges.com/story.php?title=agen-bola-%7C-agen-sbobet-%7C-agen-ibcbet
http://savinges.com/story.php?title=tips-bertaruh-di-meja-judi-bersama-agen-sbobet-terpopuler-
http://savinges.com/story.php?title=dewa-poker-%7C-agen-poker-%7C-poker-online
http://savinges.com/story.php?title=cara-bermain-poker-maha-poker
http://savinges.com/story.php?title=agen-texas-holdem-poker-online-indonesia
http://savinges.com/story.php?title=agen-bola-terpercaya-%7C-bola-tangkas-%7C-casino-sbobet
http://savinges.com/story.php?title=855online-com-agen-bola-sbobet-ibcbet-casino-338a-tangkas-togel-online-indonesia-terpercaya-2
http://savinges.com/story.php?title=pokerstar88-com-agen-texas-poker-dan-domino-online-indonesia-terpercaya
http://zonasubmit.web.id/entries/view/331638/sepakbola/agen-bola-agen-ibcbet-agen-sbobet.html
http://zonasubmit.web.id/entries/view/331639/sepakbola/agen-bola-agen-sbobet-agen-ibcbet.html
http://zonasubmit.web.id/entries/view/331640/pc/texas-poker-zyngapoker-poker-dewa.html
http://zonasubmit.web.id/entries/view/331641/gadget/sanggarhost-com-web-hosting-gratis-murah-terbaik-dan-berkualitas-di-indonesia.html
http://zonasubmit.web.id/entries/view/331642/pc/cara-bermain-poker.html
http://cepatnya.info/entries/view/560547/sepakbola/agen-bola-agen-ibcbet-agen-sbobet.html
http://cepatnya.info/entries/view/560548/sepakbola/agen-bola-agen-sbobet-agen-ibcbet.html
http://cepatnya.info/entries/view/560550/sepakbola/dewa-poker-agen-poker-poker-online.html
http://cepatnya.info/entries/view/560552/pc/agen-poker-online-terpercaya.html
http://www.perdetik.com/entries/view/475405/sepakbola/agen-bola-agen-ibcbet-agen-sbobet.html
http://www.perdetik.com/entries/view/475406/sepakbola/agen-bola-agen-sbobet-agen-ibcbet.html
http://www.perdetik.com/entries/view/475407/pc/tips-bertaruh-di-meja-judi-bersama-agen-sbobet-terpopuler.html
http://www.perdetik.com/entries/view/475408/pc/dewa-poker-agen-poker-poker-online.html
http://www.perdetik.com/entries/view/475409/pc/agen-zyngapoker-holdem-poker-games-poker.html
http://www.gamedesire.com/player/agensbobet
http://www.gamedesire.com/player/agensbobet/blog/1544166
http://www.gamedesire.com/player/agensbobet/blog/1544829
http://www.gamedesire.com/player/agensbobet/blog/1545094
http://kreepykastle.com/thedungeon/members/agensbobet/
http://kreepykastle.com/thedungeon/groups/user-agen-bola-sbobet-online-indonesia/
http://www.sba.gov/users/agensbobet
https://independent.academia.edu/AgenSbobet2
http://genius.com/agensbobet
http://x.genius.com/Agensbobet-walibolacom-sang-master-sbobet-annotated
http://www.stumbleupon.com/stumbler/agensbobetku?_notoolbar&_nospa=true
http://agensbobetku.blogdetik.com/
http://www.lautanindonesia.com/blog/agensbobetku
http://agensbobetku.blogdetik.com/layanan-terbaik-dari-agen-sbobet-dan-ibcbet-online-indonesia/
http://www.lautanindonesia.com/blog/agensbobetku/blog/43082/tips-memilih-situs-layanan-agen-sbobet-dan-ibcbet-online-indonesia
https://groups.google.com/forum/#!forum/agensbobet
https://groups.google.com/forum/#!topic/agensbobet/V1WbQF9H7ds
https://groups.google.com/forum/?hl=id#!topic/agensbobet/Xd2lfXXyGP8
https://groups.google.com/forum/?hl=id#!topic/agensbobet/dHxrcNbs0p0
https://groups.google.com/forum/?hl=id#!topic/agensbobet/tB4kjBK7Fmc
https://delicious.com/agensbobett
https://vimeo.com/user33973422
http://agensbobetku.tumblr.com/
http://id.linkedin.com/pub/agen-sbobet/a7/a19/621
http://www.emicromaryland.com/component/community/profile?userid=443
http://showmatch.it/community/3511-agensbobet/profile
http://showmatch.it/community/all-communities/viewgroup/324-agen-game-ibcbet-online-walibola-com
http://showmatch.it/community/all-communities/viewgroup/325-play-game-poker-online-di-internet
http://showmatch.it/community/all-communities/viewgroup/326-live-online-agen-judi-bola-indonesia
http://www.atheistattraction.com/index.php/my-profile/5053-agen-sbobet
http://www.atheistattraction.com/index.php/groups/viewgroup/7-link-external-to-visit
http://africancontacts.com/myprofile/agensbobet.html
http://africancontacts.com/dating-profiles/groups/viewgroup/105-Sang+Walibolacom+Agen+Ibcbet+Indonesia.html
http://thatguywiththeglasses.com/community/profile/136521-agensbobet http://walibola.com Agen Ibcbet http://bolakaca.com Agen Sbobet http://www.mahapoker.com Agen poker mahapoker.com/support/carabermain.html
http://the-infinitygroup.com Texas Poker http://ligabebek.com Agen Bola Terpercaya http://www.agenbolakaki.com Agen Bola Online http://mahabola.com http://judikita.com http://tangkaspro.com
http://friendfeed.com/agensbobet2
https://www.facebook.com/agenibcbetsbobet
http://artbistro.monster.com/member/agensbobet
http://www.last.fm/user/agensbobet
http://www.last.fm/event/3989936+Bonus+Ibcbet+Online
http://agensbobet.skyrock.com/profil/
http://agensbobet.skyrock.com/
https://www.diigo.com/user/agensbobetku
http://www.fairportbeach.com/our-community/54-agen-sbobet/profile.html
http://www.fairportbeach.com/our-community/groups/viewgroup/29-bonus-pendaftaran-agen-ibcbet-walibola-com.html
http://www.fairportbeach.com/our-community/groups/viewgroup/30-metode-cara-bermain-poker-terbaik.html
http://www.fairportbeach.com/our-community/groups/viewgroup/31-agen-bola-online-dan-agen-bola-sbobet-terpercaya.html
https://profile.yahoo.com/K43QNS7EC5XBZL4QSJAEZHFDH4/
http://wpshower.com/forums/showthread.php?t=25297
http://www.boards2go.com/boards/board.cgi?action=read&id=1415159027.99274&user=bombat
http://www.boards2go.com/boards/board.cgi?action=read&id=1415159378.88576&user=bombat
http://www.boards2go.com/boards/board.cgi?action=read&id=1415159546.58506&user=bombat
http://prague.tv/users/profile.php?who=agensbobet
https://madmimi.com/s/70f285
https://madmimi.com/p/7df285
https://plus.google.com/103492548385039909493/posts/XxigiUJH7dE
https://plus.google.com/103492548385039909493/posts/a37CwXP4gSX
http://healthylifestyleku.blogspot.com/
PokerStar88.com Agen Texas Poker Dan Domino Online Indonesia Terpercaya http://healthylifestyleku.blogspot.com/2014/11/pokerstar88com-agen-texas-poker-dan-domino-online-indonesia-terpercaya.html
https://plus.google.com/103492548385039909493/posts/XxigiUJH7dE
https://plus.google.com/103492548385039909493/posts/a37CwXP4gSX