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Frontotemporal Dementia

Treatment

Treatment of FTD is aimed at controlling symptoms pharmacologically. Most of the drugs used were already approved medications, usually used for Parkinson's disease, AD, or depression. Attempts to use levodopa, selegiline, fluoxetine, or similar drugs have not altered the course significantly but may help restless, compulsive, or apathetic behavior. Until proper randomized clinical trials are carried out, these drugs can not be considered efficacious, especially considering the variability and the relatively long clinical course of FTD.

ANDREW KERTESZ

BIBLIOGRAPHY

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HUTTON, M.; LENDON, C. L.; RIZZU, P.; et al. "Association of Missense and 5'-plice-site Mutations in Tau with the Inherited Dementia FTDP-17." Nature 393 (1998): 702–705.

KERTESZ, A.; DAVIDSON, W.; and FOX, H. "Frontal Behavioral Inventory: Diagnostic Criteria for Frontal Lobe Dementia." Canadian Journal of Neurological Sciences 24 (1997): 29–36.

KERTESZ, A.; HUDSON, L.; MACKENZIE, I. R. A.; et al. "The Pathology and Nosology of Primary Progressive Aphasia." Neurology 44 (1994): 2065–2072.

KERTESZ, A.; KAWARAI, T.; ROGAEVA, E.; et al. "Familial Frontotemporal Dementia with Ubiquitin-Positive, Tau-Negative Inclusions." Neurology 54 (2000): 818–827.

KERTESZ, A., and MUNOZ, D. G. Pick's Disease and Pick Complex. New York: Wiley-Liss, Inc., 1998.

The Lund and Manchester Groups. "Clinical and Neuropathological Criteria for Frontotemporal Dementia." Journal of Neurology, Neurosurgery and Psychiatry 57 (1994): 416–418.

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REBEIZ, J. J.; KOLODNY, E. H.; and RICHARDSON, E. P., JR. "Corticodentatonigral Degeneration with Neuronal Achromasia." Archives of Neurology 18 (1968): 20–33.

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SNOWDEN, J. S.; NEARY, D.; and MANN, D. M. A. Frontotemporal Lobar Degeneration: Frontotemporal Dementia, Progressive Aphasia, Semantic Dementia. London: Churchill Livingstone, 1996. WILHELMSEN, K. "Frontotemporal Dementia is on the MAPt." Annals of Neurology 41 (1997): 139–140.

Additional topics

Medicine EncyclopediaAging Healthy - Part 2Frontotemporal Dementia - The Clinical Syndrome Of Ftd (fld), Primary Progressive Aphasia, Corticobasal Degeneration, Pick Complex