Gene Expression: Overview of Control
When The Regulation Of Gene Expression Fails
When the control of gene expression fails, there can be serious consequences, such as death, birth defects, and cancer. Birth defects can result when the regulation of one or more genes important for development is lost. This often occurs because of a mutation, but it can also occur if the embryo or fetus is exposed to certain chemicals, such as alcohol. Mutations in the receptor for fibroblast growth factor, for instance, cause dwarfism. Cancer occurs when the regulation of genes that control growth and cell division, programmed cell death (apoptosis), and cell migration are lost.
SEEALSO ALTERNATIVE SPLICING; BIRTH DEFECTS; DEVELOPMENT, GENETIC CONTROL OF; GENE; HORMONAL REGULATION; POST-TRANSLATIONAL CONTROL; PROTEINS; RNA PROCESSING; SIGNAL TRANSDUCTION; TRANSCRIPTION; TRANSCRIPTION FACTORS.
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Medicine EncyclopediaGenetics in Medicine - Part 2Gene Expression: Overview of Control - The Flow Of Genetic Information From Genes To Proteins, Gene Control Occurs At Several Levels, How Do Cells Regulate Transcription?