Alzheimer's Disease
Conclusion
Although the human and societal cost of AD is staggering, there is hope that earlier and better diagnosis, increased knowledge of its natural history with support of the patient and family throughout the disease stages, effective symptomatic drugs, and potentially effective disease modification strategies will have a dramatic impact on the number of persons affected in the future, and the quality of life of persons currently affected. The fast pace of research and development in AD is unique in neurological history, and should lead to a better future for aging populations.
SERGE GAUTHIER
See also BRAIN; DEMENTIA; DEMENTIA, ETHICAL ISSUES; DEMENTIA WITH LEWY BODIES; ESTROGEN; FRONTO-TEMPORAL DEMENTIA; MEMORY; MEMORY DYSFUNCTION, DRUG TREATMENT; RETROGENESIS; VASCULAR DEMENTIA.
BIBLIOGRAPHY
BREINTNER, J. C. S. "The End of Alzheimer's Disease?" International Journal of Geriatric Psychiatry 14 (1999): 577–586.
GAUTHIER, S. Alzheimer's Disease in Primary Care, 2d ed. Martin Dunitz, 1999.
GAUTHIER, S. "Managing Expectations in the Long-Term Treatment of Alzheimer's Disease." Gerontology 45 (1999): 33–38.
MAYEUX, R., and SANO, M. "Treatment of Alzheimer's Disease." New England Journal of Medicine 341 (1999): 1670–1679.
MCKHANN, G.; DRACHMAN, D.; FOLSTEIN, M.; KATZMAN, R.; PRICE, D.; and STADLAN, E. M. "Clinical Diagnosis of Alzheimer's Disease: Report of the NINCDS-ADRDA Work Group Under the Auspices of Department of Health and Human Services Task Force on
Table 6 Testable hypothesis to delay onset or progression of Alzheimer's disease
MEGEER, P.; SCHULZER, M.; and MCGEER, E. "Arthritis and Anti-Inflammatory Agents As Possible Protective Factors for Alzheimer's Disease: A Review of 17 Epidemiological Studies." Neurology 47 (1996): 425–432.
REISBERG, B.; FERRIS, S. H.; DE LEON, M. J.; and CROOK, T. "The Global Deterioration Scale for Assessment of Primary Degenerative Dementia." American Journal of Psychiatry 139 (1982): 1136–1139.
ROSENBERG, R. N. "The Molecular and Genetic Basis of AD: The End of the Beginning." Neurology 54 (2000): 2045–2054.
TERRY, R. D.; MASLIAH, E. E.; SALMON, D. P.; BUTTERS, N.; DETERESA, R.; HILL, R.; HANSEN, L. A.; and KATZMAN, R. "Physical Basis of Cognitive Alterations in Alzheimer's Disease: Synapse Loss is the Major Correlate of Cognitive Impairment." Annals of Neurology 30 (1991): 572–580.
THAL, L. "Potential Prevention Strategies for Alzheimer's Disease." Alzheimer Disease and Associated Disorders 10, suppl. 1 (1996): 6–8.
WHITEHOUSE, P.; PRICE, D. L.; CLARK, A. W.; COYLE, J. T.; and DELONG, M. R. "Alzheimer Disease: Evidence for Selective Loss of Cholinergic Neurons in the Nucleus Basalis." Annals of Neurology 10 (1981): 122–126.
Additional topics
Medicine EncyclopediaAging Healthy - Part 1Alzheimer's Disease - Clinical Presentation, Diagnosis, Pathophysiology, Treatments, Conclusion