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Genetics: Gene-Environment Interaction - Summary

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The examples cited here make it clear that conclusions about the effect of a genetic locus must be interpreted cautiously. The detectability, effect size, or even direction of effect may be strongly contingent upon environmental circumstances. It is increasingly clear that the effective genotype—those loci actually being expressed at any given time—may change not only developmentally but also relatively quickly in response to an environmental alteration. It is equally the case that the effect of any environmental influence will depend upon the genotypes of the organisms exposed to that environment. Recognition of the scope for mutuality and reciprocity of genetic and environmental influences is important both for basic understanding of aging processes and for the design and application of interventions intended to extend life span and health span.

GERALD E. MCCLEARN

BIBLIOGRAPHY

BERGEMAN, C. S.; PLOMIN, R.; PEDERSEN, N. L.; MCCLEARN, G. E.; and NESSELROADE, J. R. "Genetic and Environmental Influences on Social Support: The Swedish Adoption/Twin Study of Aging." Journal of Gerontology 45 (1990): 101–106.

CAVENER, D. "Preference for Ethanol in Drosophila melanogaster Associated with the Alcohol Dehydrogenase Polymorphism." Behavior Genetics 9 (1979): 159–165.

COOPER, R. M., and ZUBEK, J. P. "Effects of Enriched and Restricted Early Environments on the Learning Ability of Bright and Dull Rats." Canadian Journal of Psychology 12 (1958): 159–164.

FOSMIRE, G. J.; FOCHT, S. J.; and MCCLEARN, G. E. "Genetic Influences on Tissue Deposition of Aluminum in Mice." Biological Trace Element Research 37 (1993): 115–121.

HELFAND, S. L.; BLAKE, K. J.; ROGINA, B.; STRACKS, M. D.; CENTURION, A.; and NAPRTA, B. "Temporal Patterns of Gene Expression in the Antenna of the Adult Drosophila melanogaster." Genetics 140 (1995): 549–555.

HOFFMAN, A. A., and PARSONS, P. A. Evolutionary Genetics and Environmental Stress. Oxford, U.K.: Oxford University Press, 1991.

JACOB, F., and MONOD, J. "Genetic Regulatory Mechanisms in the Synthesis of Proteins." Journal of Molecular Biology 3 (1961): 318–356.

LEE, C.; KLOPP, R. G.; WEINDRUCH, R.; and PROLLA, T. A. "Gene Expression Profile of Aging and Its Retardation by Caloric Restriction." Science 285 (1999): 1390–1393.

LUCKINBILL, L. S.; ARKING, R.; CLARE, M. J.; CIROCCO, W. C.; and BUCK, S. A. "Selection for Delayed Senescence in Drosophila melanogaster." Evolution 3 (1984): 996–1003.

MCCLEARN, G. E.; VOGLER, G. P.; and HOFER, S. M. "Environment-Gene and Gene-Gene Interactions." In Handbook of the Biology of Aging, 5th ed. Edited by E. J. Massoro and S. N. Austad. San Diego, Calif.: Academic Press, 2001. Chap. 16.

MCGAUGH, J. L., and COLE, J. M. "Age and Strain Differences in the Effect of Distribution of Practice on Maze Learning." Psychonomic Science 2 (1965): 253–254.

ROGINA, B., and HELFAND, S. L. "Regulation of Gene Expression is Linked to Life Span in Adult Drosophila." Genetics 141 (1995): 1043–1048.

SPROTT, R. L. "Passive-avoidance Conditioning in Inbred Mice: Effects of Shock Intensity, Age, and Genotype." Journal of Comparative Physiology and Psychology 80 (2000): 327–334.

VIEIRA, C.; PASYUKOVA, E. G.; ZENG, Z.; HACKETT, J. B.; LYMAN, R. F.; and MACKAY, T. F. C. "Genotype-environment Interaction for Quantitative Trait Loci Affecting Life Span in Drosophila melanogaster." Genetics 154 (2000): 213–227.

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