Other Free Encyclopedias » Medicine Encyclopedia » Aging Healthy - Part 1 » Accelerated Aging: Animal Models - Experimentally Induced Models, Gene-modified Models, Selection Models, Spontaneous Models

Accelerated Aging: Animal Models - Spontaneous Models

genetic journal degenerative senescence longevity

Belgian hares. A certain family of Belgian hares, part of a large breeding colony organized for the study of constitutional problems, developed premature senescence as a hereditary entity. From observations made on individuals representing twenty generations with the condition, two principal forms of the degenerative syndrome were recognized: acute and chronic (the essential difference between the two forms being the degree and rate of deterioration). However, there have been no reports on the aging characteristics and pathological findings, including histopathology, of the various degenerative lesions.

TOSHIO TAKEDA

BIBLIOGRAPHY

COVELLI, V.; MOUTON, D.; MAJO, V. D.; BOUTHILLIER, Y.; BANGRAZI, C.; MEVEL, J.-C.; REBESSI, S.; DORIA, G.; and BIOZZI, G. "Inheritance of Immune Responsiveness, Life Span, and Disease Incidence in Interline Crosses of Mice Selected for High or Low Multispecific Antibody Production." Journal of Immunology 142 (1989): 1224–1234.

FINCH, C. E. Longevity, Senescence, and the Genome. Chicago: The University of Chicago Press, 1994.

HARRISON, D. E. "Potential Misinterpretations Using Models of Accelerated Aging." Journal of Gerontology: Biological Sciences 49 (1994): B245.

ISHII, N.; FUJII, M.; HARTMAN, P. S.; TSUDA, M.; YASUDA, K.; SENOO-MATSUDA, N.; YANASE, S.; AYUSAWA, D.; and SUZUKI, K. "A Mutation in Succinate Dehydrogenase Cytochrome b Causes Oxidative Stress and Ageing in Nematodes." Nature 394 (1998): 694–697.

JEEJEEBHOY, H. F. "Decreased Longevity of Mice Following Thymectomy in Adult Life." Transplantation 12 (1971): 525–527.

KURO-O, M.; MATSUMURA, Y.; AIZAWA, H.; KAWAGUCHI, H.; SUGA, T.; UTSUGI, T.; OHYAMA, Y.; KURABAYASHI, M.; KANAME, T.; KUME, E.; IWASAKI, H.; IIDA, A.; SHIRAKI-IIDA, T.; NISHIKAWA, S.; NAGAI, R.; and NABESHIMA, Y. "Mutation of the Mouse klotho Gene Leads to a Syndrome Resembling Ageing." Nature 390 (1997): 45–51.

PEARCE, L., and BROWN, W. H. "Hereditary Premature Senescence of the Rabbit I. Chronic Form; Genertal Features." Journal of Experimental Medicine 111 (1960): 485–504.

PHILLIPS, J. P.; CAMPBELL, S. D.; MICHAUD, D.; CHARBONNEAU, M.; and HILLIKER, A. J. "Null Mutation of Copper/Zinc Superoxide Dismutase in Drosophila Confers Hypersensitivity to Paraquat and Reduced Longevity." Proceedings of the National Academy of Sciences, USA 86 (1989): 2761–2765.

POPP, D. M. "Use of Congenic Mice to Study the Genetic Basis of Degenerative Disease." Birth Defects: Original Article Series 14 (1978): 261–279.

RUSS, S., and SCOTT, G. M. "Biological Effects of Gamma Irradiation." British Journal of Radiology 120 (1939): 440–441.

SALGANIK, R. I.; SOLOVYOVA, N. A.; DIKALOV, S. I.; GRISHAEVA, O. N.; SEMENOVA, L. A.; and POPOVSKY, A. V. "Inherited Enhancement of Hydroxyl Radical Generation and Lipid Peroxidation in the S Strain Rats Results in DNA Rearrangements, Degenerative Diseases, and Premature Aging." Biochemical and Biophysical Research Communications 199 (1994): 726–733.

SELYE, H.; STREBEL, R.; and MIKULAJ, L. "A Progeria-like Syndrome Produced by Dihydrotachysterol and Its Prevention by Methyltestosterone and Ferric Dextran." Journal of the American Geriatric Society 11 (1963): 1–16.

TAKEDA, T. "Senescence-Accelerated Mouse (SAM): A Biogerontological Resource in Aging Research." Neurobiology of Aging 20 (1999): 105–110.

[back] Accelerated Aging: Animal Models - Selection Models

User Comments

The following comments are not guaranteed to be that of a trained medical professional. Please consult your physician for advice.

Your email address will be altered so spam harvesting bots can't read it easily.
Hide my email completely instead?

Cancel or