Other Free Encyclopedias » Medicine Encyclopedia » Genetics in Medicine - Part 2 » Immune System Genetics - Overview Of The Immune System, The Puzzle Of Antibody Diversity, Antibody Structure, Gene Segments Combine Randomly To Generate Diversity

Immune System Genetics - Other Sources Of Diversity

produced heavy chains cell

The random combination of V and J segments alone can produce millions of possible combinations. More diversity arises because the joining of V and J chains is done imprecisely, with the possible loss or gain of several nucleotides, resulting in added or deleted amino acids.

Remember also that each antibody includes both light and heavy chains. Heavy chains are produced by a similar combinatorial process, using a different, larger set of gene segments. The combination of a randomly produced light chain with a randomly produced heavy chain produces even more diversity. Finally, when a B cell multiplies in response to antigens, the The T cell identifies an infected cell by binding to an antigen held within an MHC molecule on the surface. rearranged gene can mutate, making some members of the clone different from others. The number of possible antibodies available through all these processes is in the trillions.

Immune System Genetics - T Cell Receptors [next] [back] Immune System Genetics - Gene Segments Combine Randomly To Generate Diversity

User Comments

The following comments are not guaranteed to be that of a trained medical professional. Please consult your physician for advice.

Your email address will be altered so spam harvesting bots can't read it easily.
Hide my email completely instead?

Cancel or