Other Free Encyclopedias » Medicine Encyclopedia » Genetics in Medicine - Part 2 » Gene Therapy: Ethical Issues - Germ Line Versus Somatic Cell Gene Therapy, Research Issues, Informed Consent, Appropriate Uses Of Gene Therapy

Gene Therapy: Ethical Issues - Promise Of Gene Therapy

genetic clinical human public nature diseases

There was extensive media coverage and public excitement about the promise of gene therapy as the first clinical trials commenced in 1990. In fact, many individuals and families with genetic disorders expected an imminent cure for their diseases. Unfortunately, there are as yet few successes to report, even though hundreds of somatic cell gene therapy clinical trials for many different diseases have been attempted. The early hype of gene therapy might have been avoided with more open and honest communication about gene therapy and its expectations between the researchers, physicians, patients, and the public. The death of the participant in 1999 and deficiencies in the protocol (study design) used for that trial underscore the need for continued public discourse on gene therapy.

The promise of gene therapy has not diminished, even though its full therapeutic potential is not yet known. Scientists, physicians, patients, and families continue to look forward to many future successes for gene therapy. With the completion of the Human Genome Project and the accelerated discovery of human disease genes, the potential number of diseases for which gene therapy could be beneficial continues to increase. With further research into the technical aspects of gene therapy and continued public debate about the ethical issues involved in such treatments, it is hoped gene therapies will become standard, effective treatments in the next few decades.

Elizabeth C. Melvin

Bibliography

Anderson, W. French. "Human Gene Therapy." Nature 392 (1998): 25-30.

Smaglik, Paul. "Congress Gets Tough with Gene Therapy." Nature 403 (2000): 583-584.

Walters, Leroy. "The Ethics of Human Gene Therapy." Nature 320 (1986): 225-227.

Internet Resources

American Society of Human Gene Therapy. <http://www.asgt.org>.

"Gene Therapy." Human Genome Program of the U.S. Department of Energy. <http://www.ornl.gov/hgmis/medicine/genetherapy.html>.

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