Other Free Encyclopedias » Medicine Encyclopedia » Aging Healthy - Part 4 » Suicide - Demographic Correlates And Methods Of Later Life Suicide, Psychological Status And Life Events Associated With Later Life Suicide

Suicide - Neurobiological Correlates Of Late Life Suicide

age aging activity increased brain risk

Postmortem brain tissue studies of suicide victims have found that the sertonergic systems (presynaptic and nontransporter nerve terminal binding sites) had reduced activity (Mann). Although there is optimism about new refinements and applications of neurobiological, brain imaging, and candidate gene markers to identify high risk individuals, there are currently no specific biological markers for suicidal behavior. With regard to older adults, it is conceivable that a ‘‘neurobiological vulnerability’’ to suicide might be modulated by age-related changes in neurobiological systems (Schneider). The consistency of increased suicide risk with age and male sex across nations also suggests a possible neurobiological process. Decreased brain concentrations of serotonin, dopamine, norepinephrine and their metabolites (HVA, 5-HIAA); increased brain MAO-B activity; increased hypothalamic-pituitary-adrenal (HPA) activity; and increased sympathetic nervous system activity are associated with both depression and normal aging (Schneider). Although several reviews have examined the evidence for neurobiologic abnormalities among older suicide victims relative to controls, there are too few studies that included sufficient ‘‘older’’ subjects (older than sixty years) to draw any conclusions (Conwell and Brent). This is particularly true of the subgroup of the older adults most at risk: those eighty-five and older.

Suicide - Suicide Attempts In Later Life [next] [back] Suicide - Psychological Status And Life Events Associated With Later Life Suicide

User Comments

The following comments are not guaranteed to be that of a trained medical professional. Please consult your physician for advice.

Your email address will be altered so spam harvesting bots can't read it easily.
Hide my email completely instead?

Cancel or