Parkinsonism

There are a wide variety of clinical syndromes that exhibit symptoms of parkinsonism, including various neurodegenerative disorders such as multiple system atrophy (MSA), dementia with Lewy bodies (DLB), corticobasal ganglionic degeneration (CBGD), and progressive supranuclear Palsy (PSP). Vascular changes can also cause parkinsonism. The other group of disorders that demonstrate parkinsonism include drug-induced parkinsonism, resulting from dopamine-receptor blockade (i.e. neuroleptics, such as thioridazine or haloperidol). Certain toxins, such as manganese and MPTP (an impurity found in certain recreational drugs) also cause parkinsonism. Metabolic disorders, such as Wilson's disease, in which copper accumulates in the brain and elsewhere, also causes parkinsonism.