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Antidepressants - Monoamine Oxidase Inhibitors (maois), Tricyclic Antidepressants (tcas), Selective Serotonin Reuptake Inhibitors (ssris)

depression

Depression in older adults is now being recognized as a severe and widespread health problem. Despite the availability of newer and safer antidepressants, depression is often unrecognized and undertreated in this population. Currently, there are several classes of antidepressants available for treatment of depression. They could be classified as monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and the miscellaneous group.

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Antidepressants - Monoamine Oxidase Inhibitors (maois)

Monoamine oxidase inhibitors (MAOIs) were the original antidepressants. MAOIs are very potent but more risky to use, particularly in older patients. MAOIs work by blocking the enzyme monoamine oxidase either reversibly or irreversibly. MAOIs that block the enzyme irreversibly are Iproniazid, Phenelzine, and Tranylcypromine. While taking these medications, patients have to avoid certain food produc…

Antidepressants - Tricyclic Antidepressants (tcas)

Tricyclic antidepressants (TCAs) work by increasing the availability of the neurotransmitters norephinephrine and serotonin in the synaptic space between nerve cells in the brain. Until recently this group of antidepressants was the "gold standard" in the treatment of late-life depression and is still used as a standard to compare newer antidepressants. This group includes medication…

Antidepressants - Selective Serotonin Reuptake Inhibitors (ssris)

Selective serotonin reuptake inhibitors (SSRIs) act by increasing the concentration of serotonin available to nerve cells. Currently the most prescribed antidepressants in the world, this group includes of citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline. The SSRIs are safer and better tolerated than MAOIs and TCAs. There is still some lingering controversy as to whether they are…

Antidepressants - Miscellaneous

There are other antidepressants that do not belong to the previous categories mentioned and are grouped together here. There is some data showing that the antidepressant buproprion is effective in late-life depression. It is thought to work by increasing the amount of dopamine available to the brain nerve cells and hence may be an attractive alternative medication. It has few interactions with ot…

Anxiety - Case One: Generalized Anxiety Disorder, Case Two: Agoraphobia, Case Three: Obsessive-compulsive Disorder [next] [back] Anti-Aging Research: Ethical and Religious Perspectives - Cautious Ethical Optimism, The Goodness Of Natural Limits, Conclusions

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